Paneth cells and necrotizing enterocolitis
نویسنده
چکیده
Necrotizing enterocolitis (NEC) is a common and devastating disease of premature infants. Immaturity of the innate immune system of the gut is central to the pathogenesis of NEC. Recent studies suggest a key role for Paneth cells in this disease. Addressing basic questions on the development and function of immature Paneth cells may shed light on the puzzling pathophysiology of NEC. Current animal models of NEC are limited in their capacity to answer these questions.
منابع مشابه
Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent inflammation and tissue necrosis. Normally, Paneth cells appear in the intestinal crypts during the first trimester of human pregnancy. Paneth cells consti...
متن کاملPaneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling
Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in premature infants. Both human surgical specimens and animal models suggest a potential involvement of Paneth cells in NEC pathogenesis. Paneth cells play critical roles in epithelial homeostasis, innate immunity and host-microbial interactions. Yet, the complex interplay between Paneth cell disruption, epithel...
متن کاملAbsence of lysozyme (muramidase) in the intestinal Paneth cells of newborn infants with necrotising enterocolitis.
AIM To determine immunocytochemically whether preterm and newborn infants with necrotising enterocolitis (NEC) show differences in numbers of lysozyme positive Paneth cells compared with normal controls, and to relate the findings to the possibility that lysozyme deficiency may facilitate the bacterial infections thought to be associated with this condition. METHODS Tissues from 10 infants wi...
متن کاملPaneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis.
Current models of necrotizing enterocolitis (NEC) propose that intraluminal microbes destroy intestinal mucosa and activate an inflammatory cascade that ends in necrosis. We suggest an alternate hypothesis wherein NEC is caused by injury to Paneth cells (PCs) in the intestinal crypts. PCs are specialized epithelia that protect intestinal stem cells from pathogens, stimulate stem cell differenti...
متن کاملPaneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like
dmm.biologists.org 522 INTRODUCTION Neonatal necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal mortality and morbidity in premature infants. In the United States, NEC affects 7% of all infants born less than 1500 g, causes the death of approximately 16-42% of those infants depending on their birth weight (Fitzgibbons et al., 2009) and increases the chance of developmental...
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